The Zika virus originated in Entebbe area of Zika Forest situated in Uganda in April 1947. It was obtained from a serum of pyrexial rhesus monkey those were caged in a canopy forest by the scientists of Yellow Fever Research Institute. Zika means “overgrown” in Luganda language. The Africans monkeys and rhesus monkeys were inoculated intracerebrally. The global spread of the Zika virus has been a major concern. This research looks into understanding how the spread of such a virus can have an impact on a country like Singapore which is an open port trading island known for being a business hub and its diverse culture. The Singapore Tourism Board is a statutory board coming under the Ministry of Trade and Industry of Singapore. The board has been highly successful in establishing the country as a major tourist attraction. We can say this as the statistics show that the country’s tourism sector accounts for about 4% of the total GDP. This has also helped the country in establishing themselves as a major attraction in terms of business, talent, and capital. The virus has been spreading rapidly and we wish to look at the impact that the virus will have on its tourism sector. This is especially important in the case of Singapore as the tourism sector contributes to about 4% of the GDP of the nation. So, if the virus does affect the state tourism sector, the economy will be hit hard.