The world health organization serves as a key employer to carry together expert along the continuum of vaccine development and regulatory approval, among its other features. Using the revision of whose tips on prophylactic human papillomavirus vaccine for instance, we describe the process by which 1) need to revise the suggestion was diagnosed 2) A collection of stakeholder with complementary expertise and key question has been diagnosed 3) a systematic evaluate turned into carried out 4) consensus on revision become carried out Updating the pointer will now boost up vaccine development, lessen costs of medical trial, and cause faster regulatory approval