An article in this paper is made to review the literature on the academic stress and adjustment on gender difference of adolescence students. The review points out about the stress and its coping techniques ( adjustment), its causal factor of stress like disturbed family, peer pressure, drug abuse, competition, inadequate studies and the problem related to stress academically of gender differences The academic stress is the most affected stress among the students of post-adolescents. The academic stress leads to weak academic performance and weak in mental health due to academic stress. The necessary to cope up with the stress in adolescents became mandatory to save the future of every nation. The objective of the study, is to study the causal factor of stress among the adolescence student of gender wise male and female, to study the impact of stress on the academic performance and mental health of the adolescents students of gender difference, to study the coping techniques of adjustment among the adolescent students of gender difference and to analyse the level of stress and adjustment experienced by adolescents male and female studying in the CBSE schools. Thus, in order to adjust with the stress various adjustment techniques should be given to students as well as parents, social support and motivation should adopt for the welfare of future pillar of every nation.