The new azomethine compound derived from Valerophenone m-Anicichydrazide has been prepared, Further, it is synthesized with Ni(II) and Zn(II) salts to form stable complexes. The ligand and metal complexes have been characterized by Elemental analysis, IR, NMR, UV/V is Spectrometry, conductivity, biological activities and Guy Balance method. The nature of bonding and the stereochemistry of the complexes have been deduced from infrared spectra, electronic spectra, magnetic susceptibility, an octahedral geometry has been suggested for Nickel (II) and tetrahedral geometry for Zinc (II) complex. The complexes are non-hygroscopic and photostable crystalline powders with different melting points. The coordination process takes place through the carbonyl oxygen and the azomethine nitrogen atom.