An isocratic liquid chromatographic method is described for simultaneous determination of Sildenafil citrate and Tadalafil in Tablets dosage forms. Chromatographic separations of both drugs was achieved on a Purosphere Star C‐8 column (150mm X4.6mm, i.d., 5μm,) using a mobile phase consisting of Water: Acetonitrile: Trifluoroacetic acid (65:35:0.1% v/v), with flow rate of 1.0ml/min and detection, was carried out at 220nm and 20ul injection volume was selected. The optimum separation was achieved in less than 15 minutes. The developed Liquid Chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. The developed method obeys beer’s law over the concentration range of 25 to 75μg/ml for Sildenafil and 5 to 15μg/ml for Tadalafil. The method was validated as per ICH guidelines and is suitable for the routine analysis of Sildenafil citrate and Tadalafil in tablet dosage forms.