Splenic marginal zone lymphoma is a rare low-grade B cell lymphoma arising from post-germinal center marginal zone B cells.comprising less than 2% of the lymphoid neoplasm; affects mainly middle-aged and elderly patients. We report a case of 58 years old female with the history of fever, malaise, and abdominal discomfort.Laboratory evaluation revealed lymphocytosis with the presence of atypical lymphocytes having villous cytoplasmic projections and basophilic cytoplasm.Immunophenotyping analysis revealed IgM positive, CD 5 negative, CD10 negative. CD23 negative and cyclin D negative.