Introduction: Meckel's diverticulum is the commonest congenital abnormality of the gastrointestinal tract. Haemorrhage, obstruction and inflammation are the three main categories of complications resulting from Meckel's diverticulum. Spontaneously perforation of Meckel's diverticulum is very rare and mimics acute appendicitis. Case: 50yr old male patient presented to the emergency room of our institute with abdominal pain for five days associated with fever with chills and complain of vomiting and anorexia. On the subsequent investigation it was found out to be a gastro-intestinal perforation. We operated the patient under general anaesthesia and intra-operative it was found out to be the Meckel’s diverticular perforation. So, we have done resection of contained part and done ileo-ileal anastomosis. Discussion: Meckel’s diverticulum is the result of dysgenesis of the small bowel as it develops in relation to the embryologic yolk sack and arises from the incomplete obliteration of the vitelline duct between the 5th and 8th weeks of gestation. Perforation is an uncommon complication of MD, and the symptom can mimic other acute abdominal conditions such as acute appendicitis as well as gynaecological and urological condition while in the emergency space. We should take diagnosis under consideration as a differential diagnosis when we encounter patients whose impression was firstly acute appendicitis and treatment should be followed accordingly.