Though symptoms of Liver disorders are challenging, Siddha system of medicine ameliorates them in a very effective way. This research aimed to evaluate the Hepatoprotective activity of Siddha herbo mineral preparation Arithiraadhi chooranam by CCl4 induced hepatotoxicity in albino rats. Administration of Arithiraadhi chooranam significantly reduced the impact of CCl4 toxicity. Protection of hepatocytes was evaluated by estimating the level of ALT, AST, ALP, serum bilirubin, and total protein. The results strongly indicates that Arithiraadhi chooranam has appreciable hepatoprotective potential.