Laboratory health-care technicians, including microbiologists, pathologist, chemists and etc, are exposed to a number of risk factors in the workplace for musculoskeletal disorders (MSDs). But, the individual effect of these risk factors on laboratory technicians in Libya is unknown. Objective: The aim of this study was to know the risk factors and its individual contribution for work-related MSDs (WMSDs) among laboratory technicians in health care system. Materials and Methods: Descriptive Cross-Sectional study, done on laboratory health-care technicians in Benghazi Medical Centre (BMC). Risk factors were categorized into personal and workstation which was known using questionnaire and RULA checklist. Outcomes: A total of 103 subjects participated randomly in the study. Data outcomes display that all the study participants are at ergonomic risk caused by static & repetitive working postures during laboratory tasks such as computer workstation and pipetting workstation that were found to be the most important contributory factors in WMSDs. Conclusion: Medical laboratory technicians are strongly encouraged to adopt preventive measures toward personal and workstation-related risk factors before symptoms of WMSDs develop.