Background: Abnormal Uterine Bleeding (AUB)- a term used to describe any type of bleeding that does not fall within the normal ranges for the amount, frequency, duration, or cyclicity. The estimated worldwide prevalence of subjective, self-defined abnormal uterine bleeding varies greatly from 4% to 52%. It is one of the frequently encountered gynecological problems responsible for about one-third of patients visiting gynecological OPD. It interferes with a women’s physical, social and emotional quality of life. Objective: The aim of the study was to evaluate the efficacy of tukhme khurfa(Portulaca oleracea seeds) in the management of abnormal uterine bleeding. Material and methods: The study was designed, an open observational clinical study conducted in the Dept. of Ilmul Qablat was Amraze Niswan, NIUM hospital, Bengaluru. 30 women age group of 18-45 years with abnormal uterine bleeding were allocated. Roasted powder of tukhme khurfa in the form of the capsule (2gms) thrice a day was given for two consecutive cycles. Follow up was done before and after each menstrual cycle during treatment and after treatment once in a month for two consecutive cycles. Primary and secondary outcomes were assessed by Pictorial blood assessment chart (PBAC) at each follow-up. Hemoglobin percentage, Short form survey (SF-12), menstrual regulation, before and after treatment. Results: Statistical analysis was done by using Fisher exact. There was the significant reduction in PBAC score, improvement in SF-12 score with the p-value of < 0.001. The menstrual regulation also achieved in 26(86.7%) out of 30 patients. Interpretation and conclusion: Tukhme khurfa can be considered as an effective alternative medicine in the management of abnormal uterine bleeding. There was no adverse effect noted.