Studies using Homoepathy have reported beneficial effects from treating in cholelithiasis. Cholelithiasis is a clinical syndrome characterized by pain in the upper abdomen especially in the right hypochondriac region, back between the shoulder blades and right shoulder followed by nausea and vomiting. Cholelithiasis is a global health problem that is often treated with homeopathy. The objective of this review will be to evaluate the effectiveness of homoeopathic medicines in Cholelithiasis with Hydrastis. The clinical study was undertaken with an aim to prove the efficacy of Homoeopathic medicines in cases of Cholelithiasis at Bhartish Homoeopathic Medical College, Hospital and Research center, Karnataka. All indicated homoeopathic medicines on the base of a totality of symptoms which prove beneficial for all the case and thus the effectiveness of homoepathic medicines was proved in the treatment of Cholelithiasis with Hydrastis. Material Methods: Total 30 patients of cholelithiasis are selected in this observation study. Result: over a period of December 2014 to December 2016, all indices throughout the follow-up period, this reduction was seen in cholelithiasis. Result: out of 30 cases, 22 (73.33%) patients are got recovered, 6 (20%) patients are improved and 2 (6.66%) patients are not improved. Conclusion: There is a significant re-education of pain and other symptoms of cholelithiasis.