The survival of organizations, especially universities, depends largely on the nature of the strategies that are formulated and how to deal with them in the light of changes. The organizations are looking for ways to succeed in this task and looking for the strategic factors that contribute to achieving organizational sustainability. And the concept of strategic physiognomy as a modern term in science. This study aims to identify the effect of strategic physiognomy on organizational sustainability. The conceptual model was formulated through the components of strategic physiognomy (Empowerment, Inspiration, Deep Understanding) and its relation to organizational sustainability. The results indicated that strategic physiognomy has directly and significantly impacted on organizational sustainability.