Worm infestation is one of the silent diseases which is prevalent in developing countries especially India. Worm infestation are more prevalent among school children. It can result in impaired nutrition and poor development of children. Knowledge of the worm infestation can assist in early detection of the diseases and reduce the incidence of complications.The present study was carried out to assess the effectiveness of health educational package on knowledge regarding prevention of worm infestation among school going children studying at selected schools of Punjab.A pre-experimental study with one group-pretest and posttest design by using simple random sampling. 250 school going children were selected. Health educational program was used to establish the pre-test knowledge score and health educational program was administered for selected school going children and post-test was conducted to establish the effectiveness of health educational package on knowledge regarding prevention of worm infestation .It is evident from the result that pre-test knowledge mean score was found to be 11.54 as compared to the post test mean score of 16.41. Further the enhancement of mean score was found to be 4.87. However, the statistical paired t-test indicate the enhancement of knowledge was found to be highly significant (t= 12.88, p< 0.05) revealing the effectiveness of health educational package on knowledge regarding prevention of worm infestation.It is concluded that health educational program showed highly significant effect on knowledge regarding prevention of worm infestation.