Endodontic therapy or root canal therapy is the treatment modality for the infected pulp of a tooth which results in the elimination of infection and the protection of the decontaminated tooth from future microbial invasion. Many endodontic patients believe that post-treatment pain is unavoidable, yet several clinical trials indicate that postoperative pain occurs in only 25–40% of all endodontic patients. However, post-treatment pain may last up to several days, depending upon the treatment. Hence, successful management of endodontic pain is an important concern for patients. This Research will include the comparison of prescription of medicines, post-endodontic treatment.