Introduction: Lymphomas are solid tumors of the immune system. Hodgkin's lymphoma accounts for about 10% of all lymphomas, and the remaining 90% are referred to as non-Hodgkin lymphoma. Non-Hodgkin lymphomas have a wide range of histological appearances and clinical features at presentation, which can make diagnosis difficult. Case report: A 60-year-old male presented with the chief complaint of swelling in the bilateral inguinal region since 8 months associated with a headache. On examination, multiple enlarged superficial groups of lymph nodes noted bilaterally measuring 57x36 mm on the right side and 50x32 cm on left side. Radiological findings are suggestive of bilateral inguinal lymphadenopathy. A core gun biopsy was done and sent for histomorphological examination. Histomorphologically non-Hodgkin lymphoma was diagnosed and confirmed by performing different IHC markers. Discussion: Non-Hodgkin's lymphoma symptoms may include: Swollen lymph nodes in neck, armpits or groin, abdominal pain or swelling, fatigue, fever, night sweats, weight loss. Non-Hodgkin's lymphoma generally involves the presence of cancerous lymphocytes most commonly in lymph nodes. In this particular case diagnosis of non-Hodgkin's lymphoma is given on core gun biopsy specimen instead of an excised lymph node specimen. Conclusion: An adequate core gun biopsy specimen is sufficient for making a diagnosis of cancer like non-Hodgkin's lymphoma.